The WFS workshop 2021 will be a hybrid meeting hosted in Valparaiso, Chile, with simultaneous online participation. The WFS Workshop 2021 is planned as a single track meeting with several sessions devoted to share and discuss over the latest advancements in WFS technologies and applications, while discussing its implications in AO systems. Along with a series of invited speakers (to be announced shortly), there will also be a special session on current applications and trends of artificial intelligence and deep learning in the design and improvement of WFSs and wavefront reconstruction.